The Rafael Núñez International Airport (IATA: CTG, ICAO: SKCG) of Cartagena de Indias is the largest airport in the country's northern Caribbean region in terms of passenger movement.

Airlines including Copa Airlines Colombia, Copa Airlines, Avianca, JetBlue, Spirit Airlines, and Delta Air Lines have international flights from this airport to various cities in North, Central and South America, with direct flights to/from Miami, Fort Lauderdale, Panama City, and Santiago de Chile.

KLM and Meridiana are European Airlines flying at this airport.

In addition, 20 or more daily flights of 90 minutes connect the Rafael Núñez and the Bogota El Dorado International Airport.

Bogota El Dorado is the largest airport in Colombia and the main international and domestic air gateway in the country, serving as the main and largest hub for Avianca (the national flag carrier of Colombia), Copa Airlines Colombia, LATAM, Satena, and EasyFly.